Publications

Research Papers

2025

  • Wu, J., Yarmey, V. R., Yang, O. J., Soderblom, E. J., San-Miguel, A., & Yan, D. (2025). Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging. Nature Neuroscience, 28(8), 1635–1648. https://doi.org/10.1038/s41593-025-01989-0. Online Link
  • Sohail, M., Cheadle, J., Khan, R., Mane, H., Samaher Salem, K., Ernst, K., San Miguel, A., Opperman, C. H., Pirzada, T., Crook, N., & Khan, S. A. (2025). Pickering Emulsion for Enhanced Viability of Plant Growth Promoting Bacteria and Combined Delivery of Agrochemicals and Biologics (Adv. Funct. Mater. 24/2025). Advanced Functional Materials, 35(24), 202570139. https://doi.org/10.1002/adfm.202570139. Online Link
  • Lichty, J. D., Mane, H., Yarmey, V. R., & Miguel, A. S. (2025). Amyloid β induces hormetic-like effects through major stress pathways in a C. elegans model of Alzheimer’s Disease. PLOS ONE, 20(4), e0315810. https://doi.org/10.1371/journal.pone.0315810. Online Link
  • Karakis, V., Britt, J. W., Jabeen, M., San Miguel, A., & Rao, B. M. (2025). Derivation of human trophoblast stem cells from placentas at birth. Journal of Biological Chemistry, 301(6), 108505. https://doi.org/10.1016/j.jbc.2025.108505. Online Link
  • Jabeen, M., Karakis, V., Britt, J., Miguel, A. S., & Rao, B. (2025). A quantitative image analysis platform for assessing trophoblast differentiation. Placenta, 166, 117–125. https://doi.org/10.1016/j.placenta.2024.07.009. Online Link
  • Gomez, K., Yarmey, V. R., Mane, H., & San-Miguel, A. (2025). Microfluidic and Computational Tools for Neurodegeneration Studies. Annual Review of Chemical and Biomolecular Engineering, 16(Volume 16, 2025), 195–216. https://doi.org/10.1146/annurev-chembioeng-082223-054547. Online Link

2024

  • Lin, K. N., Volkel, K., Cao, C., Hook, P. W., Polak, R. E., Clark, A. S., San Miguel, A., Timp, W., Tuck, J. M., Velev, O. D., & Keung, A. J. (2024). A primordial DNA store and compute engine. Nature Nanotechnology, 19(11), 1654–1664. https://doi.org/10.1038/s41565-024-01771-6. Online Link
  • Durmusoglu, D., Haller, D. J., Al’Abri, I. S., Day, K., Sands, C., Clark, A., San-Miguel, A., Vazquez-Uribe, R., Sommer, M. O. A., & Crook, N. C. (2024). Programming Probiotics: Diet-Responsive Gene Expression and Colonization Control in Engineered S. boulardii. ACS Synthetic Biology, 13(6), 1851–1865. https://doi.org/10.1021/acssynbio.4c00145. Online Link
  • Clark, A. S., Huayta, J., Morton, K. S., Meyer, J. N., & San-Miguel, A. (2024). Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans. NeuroToxicology, 100, 100–106. https://doi.org/10.1016/j.neuro.2023.12.005. Online Link
  • Yarmey, V. R., & San-Miguel, A. (2024). Biomarkers for aging in Caenorhabditis elegans high throughput screening. Biochemical Society Transactions, 52(3), 1405–1418. https://doi.org/10.1042/BST20231303. Online Link

2023

  • Clark, A., Kalmanson, Z., Morton, K., Hartman, J., Meyer, J., San Miguel, A. “An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans” PLOS One. 2023, 18(7), e0281797. Online Link
  • Huayta, J., Crapster, J., San-Miguel, A. “Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction.” Communications Biology, 2023, 6, 203. Online Link
  • Prodromou, R., Moore, B. D., Chu, W., Deal, H., San Miguel, A., Brown, A. C., Daniele, M. A.-A., Pozdin, V. A., Menegatti, S., “Molecular Engineering of Cyclic Azobenzene-Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo-Affinity Chromatography” Advanced Functional Materials. 2023, 33, 2213881. Online Link
  • Karakis, V., McDonald, T., Cordiner, A., Mischler, A., San Miguel, A., Rao, B.M. “Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions.” Journal of Biological Chemistry, 2023, 299, 104650. Online Link

2022

  • Midkiff, D; San-Miguel, A. “Identifying C. elegans Lifespan Mutants by Screening for Early-Onset Protein Aggregation.” iScience. 2022. doi: 10.1016/j.isci.2022.105460. Online Link

2021

  • Arulalan, K. S., Huayta, J., & San-Miguel, A. (2021). Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction. Exposome, 005, 1–18. Online Link
  • Clark, A. S., Huayta, J., Arulalan, K. S., & San-Miguel, A. (2021). Microfluidic devices for imaging and manipulation of C. elegans. Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms, 295–321. ISBN: 9780128239902
  • San-Miguel, A. (2021). Optogenetics gets the worm. Science Robotics, 6(55), 1–3. https://doi.org/10.1126/scirobotics.abj3937 Online Link
  • Clark, A.S., & San-Miguel, A. (2021). A bioinspired, passive microfluidic lobe filtration system. Lab on a Chip, 2021, DOI: 10.1039/D1LC00449B Online Link
  • Mischler A., Karakis V., Mahinthakumar J., Carberry C.K., San Miguel A., Rager J.E., Fry R.C., Rao B.M. (2021). Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem. 2021 Feb 5;:100386. doi: 10.1016/j.jbc.2021.100386. PubMed PMID: 33556374; PubMed Central PMCID: PMC7948510. Online Link
  • Prodromou R., Day K.N., Saberi-Bosari S., Schneible J.D., San Miguel A., Daniele M.A., Pozdin V., Menegatti S. (2021). Engineering Next Generation Cyclized Peptide Ligands for Light‐Controlled Capture and Release of Therapeutic Proteins. Advanced functional materials. Forthcoming. doi: doi.org/10.1002/adfm.202101410. Online Link
  • Smith, K. M., San-Miguel, A., & Hsiao, L. C. (2021). Local velocity of thermoresponsive colloidal gels in rate-driven flow Local velocity of thermoresponsive colloidal gels in rate-driven flow. Physics of Fluids, 033113(December 2020). https://doi.org/10.1063/5.0042109 Online Link

2020

  • Saberi-Bosari, S., Flores, K. B. & San-Miguel, A. (2020). Deep learning-enabled phenotyping reveals distinct patterns of neurodegeneration induced by aging and cold-shock. BMC Biol. 2020.03.08.982074 . Online Link
  • Crawford, Z., & San-Miguel, A. (2020). An inexpensive programmable optogenetic platform for controlled neuronal activation regimens in C . elegans, APL Bioeng. 4, 01610. Online Link
  • Lee M.H., Luo H.R., Bae S.H., San-Miguel A. (2020). Genetic and Chemical Effects on Somatic and Germline Aging, Oxid Med Cell Longev. 2020;2020:4684890. doi: 10.1155/2020/4684890. eCollection 2020. PubMed PMID: 32377299; PubMed Central PMCID: PMC7182970. Online Link
  • Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Coté AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovács IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D’Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Taşan M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP, Calderwood MA. (2020). A reference map of the human binary protein interactome. Nature. 2020 Apr;580(7803):402-408. doi: 10.1038/s41586-020-2188-x. Epub 2020 Apr 8. PubMed PMID: 32296183; PubMed Central PMCID: PMC7169983. Online Link

2019

  • Midkiff, D., & San-Miguel, A. (2019). Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans. Molecules (Basel, Switzerland), 24(23).  Online Link
  • Saberi-Bosari, S., Omary, M., Lavoie, A., Prodromou, R., Day, K., Menegatti, S., San-Miguel, A.  (2019). Affordable Microfluidic Bead-Sorting Platform for Automated Selection of  Porous Particles Functionalized with Bioactive Compounds, Scientific Reports 9, Article Number: 7210.  Online Link 
  • Day, K., Prodromou, R., Saberi Bosari, S., Lavoie, A., Omary, M., Market, C., San-Miguel, A., Menegatti, S. (2019). Discovery and Evaluation of Peptide Ligands for Selective Adsorption and Release of Cas9 Nuclease on Solid Substrates. Bioconjugate Chemistry, 30(12), 3057–3068. Online Link

2018

  • Saberi-Bosari, S., Huayta, J., San-Miguel, A. (2018). A microfluidic platform for lifelong high resolution and high-throughput imaging of subtle aging phenotypes in C. elegans, Lab on a Chip, 2018, 18, 3090 – 3100.  Online Link

        Highlight: Selected for the front cover of Lab on a Chip!  Online Link 

2016

  • San-Miguel, A., Kurshan, P. T., Crane, M. M., Zhao, Y., McGrath, P. T., Shen, K., & Lu, H. (2016). Deep phenotyping unveils hidden traits and genetic relations in subtle mutants. Nature Communications, 7.  Online link.
  • Porto, D. A., Rouse, T. M., San-Miguel, A., & Lu, H. (2016). Microfluidic Platforms for Quantitative Biology Studies in Model Organisms. In Microfluidic Methods for Molecular Biology (pp. 1-18). Springer International Publishing. Online link.

2015

  • Sahni, N., Yi, S., Taipale, M., Bass, J. I. F., Coulombe-Huntington, J., Yang, F., … & Kovács, I. A. (2015). Widespread macromolecular interaction perturbations in human genetic disorders. Cell, 161(3), 647-660. Online link.
  • He, L., Kniss, A., San-Miguel, A., Rouse, T., Kemp, M. L., & Lu, H. (2015). An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies. Lab on a Chip, 15(6), 1497-1507. Online link.

2014

  • Maeder, C. I., San‐Miguel, A., Wu, E. Y., Lu, H., & Shen, K. (2014). In Vivo Neuron‐Wide Analysis of Synaptic Vesicle Precursor Trafficking. Traffic, 15(3), 273-291. Online link.

2013

  • San-Miguel, A., & Lu, H. (2013). Microfluidics as a tool for C. elegans research. Wormbook, ed. The C. elegans Research Community. Online link.
  • Scrimgeour, J., San-Miguel, A., Curtis, J. E., & Behrens, S. H. (2013). A generalized approach for measuring microcapsule permeability with Fluorescence Recovery After Photobleaching. Journal of Materials Science, 48(5), 2215-2223. Online link.

2012

  • San-Miguel, A., & Behrens, S. H. (2012). Influence of nanoscale particle roughness on the stability of Pickering emulsions. Langmuir, 28(33), 12038 -12043. Online link.

2011

  • San Miguel, A., & Behrens, S. H. (2011). Permeability control in stimulus-responsive colloidosomes. Soft Matter, 7(5), 1948-1956. Online link.

2010

  • Rubin, J., San Miguel, A., Bommarius, A. S., & Behrens, S. H. (2010). Correlating Aggregation Kinetics and Stationary Diffusion in Protein− Sodium Salt Systems Observed with Dynamic Light Scattering. The Journal of Physical Chemistry B, 114(12), 4383-4387. Online link.
  • San Miguel, A., Scrimgeour, J., Curtis, J. E., & Behrens, S. H. (2010). Smart colloidosomes with a dissolution trigger. Soft Matter, 6(14), 3163-3166. Online link.

Book Chapters

  • Clark, A.*, Huayta, J.*, Suresh Arulalan, K.*, San Miguel, A., “Microfluidics devices for imaging and manipulation of C. elegans” Peer-reviewed book chapter in: Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms. Academic Press, 2021, 295-321. Online Link
  • Porto, D.A., Rouse, T.M., San-Miguel, A., Lu, H.. “Microfluidic platforms for genetic and genomic studies in model organisms.” Microfluidic Methods for Molecular Biology. 2016, 1-18. Online Link

Other Publications

  • San-Miguel, A. “Optogenetics gets the Worm”. Science Robotics. 2021, 6(55), eabj3937. Focus article (commentary). Online Link
  • Huayta, J., Flores, K., San-Miguel, A. “Lifelong Analysis of Key Aging Genes as Determinants of Lifespan in C. elegans” The FASEB Journal. 2020, 34, 1. Abstract for Experimental Biology 2020 Meeting. Online Link
  • Lee, M.H., Luo, H.R., Bae., S.H., San-Miguel, A. “Genetic and Chemical Effects on Somatic and Germline Aging” Editorial in Oxidative Medicine and Cellular Longevity. 2020. 4684890. Online Link